Vopr Kurortol Fizioter Lech Fiz Kult. 2015 Sep-Oct;92(5):50-3.

The application of laser therapy for the medical rehabilitation of the children presenting with chronic osteomyelitis.

[Article in Russian]
Trunova OV, Mashkov AE, Khan MA, Prikuls VF, Nazarenko NN, Supova MV, Smirnova SN, Larionov KS.


The objective of the present study was to develop a scientifically sound rationale for the application of infrared laser radiation (IRLR) either separately or in the combination with fluctuation magnetic therapy in the medical rehabilitation of the children presenting with chronic hematogenous osteomyelitis. Another objective was to evaluate the clinical effectiveness of this therapeutic modality. Two achieve these goals, the clinical observations and special research studies were conducted in two directions with the participation of 95 patients at the age varying from 1 to 15 years. The study has demonstrated the effectiveness of the inclusion of IRLR in the medical rehabilitation program for the children with chronic hematogenous osteomyelitis in different periods of the disease. It was shown that the transcutaneous infrared irradiation of the affected area during the exacerbation of chronic osteomyelitis had a well apparent immunostimulatory effect and reduced the activity of the inflammatory process. The application of IRLR in combination with fluctuation magnetic therapy during the period of partial remission, had a more pronounced influence on the microcirculation and stimulated the regenerative and trophic processes.

Photomed Laser Surg.  2011 Jun;29(6):405-12. Epub 2011 Jan 10.

The use of 808-nm light therapy to treat experimental chronic osteomyelitis induced in rats by methicillin-resistant Staphylococcus aureus.

Kaya G, Kaya M, Gürsan N, Kireççi E, Güngörmü M, Balta H.


Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Atatürk University, Erzurum, Turkey. gokselsimsek@yahoo.com



In vivo and in vitro studies have reported that laser energy in differing wavelengths and irradiation regimes has a potential bactericidal effect on Staphylococcus aureus.


The purpose of this study was to investigate whether a light wavelength of 808 nm in varying doses has an effect on chronic osteomyelitis induced experimentally in the rat tibia.


Intramedullary cavities were surgically created in the left tibias of 39 adult Wistar albino rats. Five randomly selected subjects were injected with a sterile saline solution, and methicillin-resistant S. aureus (MRSA) was used to induce osteomyelitis in the remaining rats. After 3 weeks, rats with evidence of osteomyelitis were treated with debridement alone (n=7), with debridement plus laser irradiation to induce photoeradication (n=21), or were not treated at all [negative control, (n=6)]. Active irradiation was performed using an 808 nm, 100 mW continuous-wave diode laser with a beam spot size of 0.7854 cm(2) (irradiance=127.3 mW/cm(2)). Laser treatment commenced immediately after debridement surgery and was applied daily for 5 consecutive days. Irradiation lasted 60 secs (6 J at 7.64 J/cm(2): n=7), 120 secs (12 J at 15.29 J/cm(2): n=7), or 180 secs (18 J at 22.93 J/cm(2): n=7). Rats in the sham and negative control groups were killed 21 days post-induction surgery, and those in the treatment groups were killed after 42 days. Following killing, tibias were removed and analyzed histopathologically, radiographically, and microbiologically.


Histopathological analysis showed that infection levels had decreased by 37%, 67%, 81%, and 93% in the groups treated by debridement or by debridement plus 7.64, 15.29, and 22.93 J/cm(2) light therapy, respectively, compared to the negative control group. Osteomyelitis-induced rats had the highest bacteria count (5×10(5)). Bacterial counts fell to 1.6×10(4), 4.3×10(2), 5.5×10(1), and 3.3×10(0) in groups treated by debridement or by debridement plus 7.64, 15.29, and 22.93 J/cm(2) light therapy, respectively, compared to the negative control group.


Within the limitations of this study, laser phototherapy with the appropriate irradiation parameters appears to be a promising adjunct and/or alternative technique to pharmacological agents in the treatment of osteomyelitis. The 808 nm 100 mW (127.3 mW/cm(2)) laser device used in this study achieved a maximum effect with an irradiation time of 180 secs, delivering 18 J at an energy density of 22.93 J/cm(2).

Adv Gerontol. 2011;24(1):130-4.

Treatment of patients of elderly and sinile age with fractures of the mandibula.

[Article in Russian]
Guk VA, Iordanishvili AK, Ryzhak GA.


In the above study, the comparison of efficiency of complex treatment of elderly and senile patients with fractures of mandibula has been carried out. After osteosynthesis of mandibula with mini-plates, frequency of development of traumatic osteomyelitis in these patients was lower than that after osteosynthesis by means of bone suture, especially in the group of patients who were admitted with signs of inflammation of osteal wound, where traumatic osteomyelitis developed 3 times less often than after osteosynthesis with bone suture. At bilateral fractures of mandibula, osteosynthesis with bone suture is not prescribed to the elderly patients who are admitted with signs of inflammation of osteal wound. Application of mini-plates for osteosynthesis at fractures of mandibula in the elderly patients enabled to restore mandibula motion and chewing function within much earlier terms.

J Zoo Wildl Med.  2010 Dec;41(4):703-9.

Successful treatment of chronic periapical osteomyelitis in a Parma wallaby (Macropus parma) using comprehensive endodontic therapy with apicoectomy.

Kilgallon CP, Bicknese B, Fagan DA.

Zoological Society of San Diego, San Diego Wild Animal Park, 15500 San Pasqual Valley Road, Escondido, California 92027, USA. conchubhair2001@yahoo.co.uk


Although necrobacillosis remains a common condition of captive macropods, there have been limited reports of successful treatment modalities by which it can be treated. Comprehensive endodontic therapy with apicoectomy has been used reliably in human and domestic animal dentistry. This report describes a case of periapical osteomyelitis involving a mandibular incisor in a Parma wallaby (Macropus parma) that was successfully treated using these techniques in conjunction with low-level laser therapy at 810 nm, which was used for decontamination of the pulp cavity, anti-inflammatory, and biostimulatory effects.

EMLA Laser Health J 2007;2:46-67
European Medical Laser Association (EMLA)

The effect of low level laser therapy on chronic osteomyelitis: a case report

Kazemi-Khoo N.

Iran University of Medical Science, Head Office of Laser Center of Milad Hospital
prof Ismailov

Low level laser therapy (LLLT) could increase tissue perfusion, reinforcement of immune system and may have antibacterial effect. In this article we report the successful treatment of chronic osteomyelitis by LLLT.

Patient was a 16-year-old girl who had been severely injured in a truck accident. Her right metatarsal bones were crushed and resistant osteomyelitis complicated the patient, but she rejected amputation. She referred to our laser center due to chronic osteomyelitis with a discharging fistula. Antibiotics (ceftrixone and cloxacillin prescribed according to the culture showed Staphylococcus aureus). We also applied laser with a dose of 10-12 J/cm 2, using continuous infrared light (wavelength 980 nm, power 100 mW) and continuous red light (wavelength 650 nm, power 30 mW), 3 times a week for 4 weeks and then 2 times a week until discharge was disappeared (totally 28 sessions).

After a month fistula discharged again and the same laser protocol along with laser acupuncture was applied for 23 sessions. This treatment was successful and after 3 months Elizarov’s surgery was done. At this time (10 month after the last session of laser therapy) she can stand straight and walk.

Stomatologiia (Mosk). 2003;82(3):32-7.

Treatment of inflammatory pyodestructive processes of the oral cavity, maxillofacial area, and neck by laser and magnetic-laser exposure of the carotid sinus using the Optodan laser apparatus.

[Article in Russian]
Zhizhina NA, Prokhonchukov AA, Vakhtin VI, Geniuk VIa.


This paper presents the priority original methods (patent No. 2101046, Russia) for the treatment of inflammatory pyodestructive processes in the oral cavity, maxillofacial area, and neck (odontogenic abscesses and phlegmons including those complicated by mediastinitis and sepsis), sinusitis, carbuncles and furuncles of face and neck skin, parotitis, sialadenitis, adenophlegmons, lymphadenitis, periotitis, alveolitis, arthritis, arthrosis of the temporomandibular joint, odontogenic and traumatic osteomyelitis, infected purulent traumas (including gunshot ones), fractures of the jaws, etc. making use of Optodan laser (patent No. 2014107, Russia) for laser and magnetic-laser therapy.

Khirurgiia (Mosk). 2002;(12):42-4.

[Omentoplasty in surgical treatment of osteomyelitis of the ribs and sternum].

[Article in Russian]
Shipulin PP, Smirnov AB, Martyniuk VA, Brizitski? VV.


Seven-year experience in the treatment of 21 patients with chronic osteomyelitis of the ribs and sternum is summarized. Great omentum was used as plastic and disinfecting material in combination with laser radiation. Indications, techniques, short- and long-term results are presented. There were no recurrences of purulent process in the bones. Omentoplasty is the method of choice in surgical treatment of purulent lesions of costal cartilage and sternum.