Morphine withdrawal sign attenuation

Behav Brain Res. 2008 Sep 24. [Epub ahead of print]

Attenuation of morphine withdrawal signs by low level laser therapy in rats.

Mirzaii-Dizgah I, Ojaghi R, Sadeghipour-Roodsari HR, Karimian SM, Sohanaki H.

Department of Physiology, School of Medicine, AJA University of Medical Sciences, Tehran, Iran; Clinical Research Center, Qom University of Medical Sciences, Qom, Iran.

In the present study, the effects of low-intensity laser therapy (LILT) on naloxone-induced withdrawal signs of morphine-dependent rats were examined. Low-intensity lasers with a power density of 12.5J/cm(2) have been used by a Ga-Al-As laser. One-way ANOVA showed that the LILT which applied immediately or 15min prior to naloxone injection significantly decreased total withdrawal score (TWS). These results suggest that LILT prior to naloxone injection attenuates the expression of withdrawal signs in morphine-dependent rats. Further studies may elucidate the likely role of LILT in clinical management of opioid withdrawal syndrome.