Sjogren’s Syndrome

Med Pregl.  2012 May-Jun;65(5-6):247-50.

The effects of low-level laser therapy on xerostomia (mouth dryness).

[Article in Serbian]
Pavlic V.


Katedra za parodontologiju i oralnu medicinu, Medicinski fakultet, Univerzitet u Banjaluci.



Xerostomia is a subjective complaint of mouth/oral dryness, caused by a reduction in normal salivary secretion due to different causes. Even though there are many available treatment modalities to enhance salivary flow, the therapy often remains unsatisfactory. The low-level laser therapy (low-level laser irradiation, photo-biomodulation) has been extensively used as a new, non-invasive approach and advantageous tool for reduction of xerostomia. Therefore, the aim of this study is to give a systematic overview on the effects of low-level laser therapy on xerostomia.


A systematic review of published articles in PubMed database was carried out using keywords: “low-level laser therapy”, “xerostomia”, “mouth dryness”.


In all published articles, which were considered adequate for this overview, positive effects of low-level laser therapy were reported. Low-level laser therapy could significantly enhance salivary secretion and improve antimicrobial characteristics of secreted saliva (increased level of secretory immunoglobulin A; sIgA). Furthermore, low-level laser therapy could improve salivary flow and regeneration of salivary duct epithelial cells.


The current literature suggests that low-level laser therapy can be safely and effectively used as an advanced treatment modality for reduction of xerostomia. Further in vivo, in vitro and clinical studies using different irradiation parameters are suggested to determine the best laser parameters to be used.

Spec Care Dentist. 2009 May-June;29(3):134-7.

Laser as a therapy for dry mouth symptoms in a patient with Sjögren’s syndrome: a case report.

Simões A, Platero MD, Campos L, Aranha AC, Eduardo Cde P, Nicolau J.

Oral Biology Research Center, Department of Biomaterials and Oral Biochemistry, School of Dentistry, University of São Paulo, São Paulo, Brazil.

This clinical case study reports on dry mouth symptoms in a patient with Sjögren’s syndrome (SS) who was treated with laser phototherapy (LPT). A 60-year-old woman diagnosed with SS was referred to the laboratory for lasers in dentistry to treat her severe xerostomia. A diode laser (780 nm, 3.8 J/cm2, 15 mW) was used to irradiate the parotid, submandibular, and sublingual glands, three times per week, for a period of 8 months. The salivary flow rate and xerostomia symptoms were measured before, during, and after LPT. Dry mouth symptoms improved during LPT. After LPT, the parotid salivary gland pain and swelling were no longer present. Treatment with LPT was an effective method to improve the quality of life of this patient with SS.

Stomatologiia (Mosk).  1989 Mar-Apr;68(2):35-6.

Treatment of inflammatory salivary gland diseases by using intraductal UV irradiation.

[Article in Russian]
Afanas’ev VV, Robustova TG, Romacheva IF, Ter-Markar’ian MO, Makeeva NS.


A novel technique is offered for treatment of sialadenitis. Ultraviolet irradiation conductors are inserted into the gland via its major duct for subsequent intracorporeal UV therapy of the gland. The results of the treatment are analyzed in 57 cases of sialadenitis observed during 1 to 2.5 years. The technique proved effective enough to be recommended for practical application.